POPout is a software tool to apply the "PRS-on-Phenotype outlier" (POPout) test. The POPout test was developed to test for departures from common-variant expectations in the tails of trait distributions. Users with PRS and quantitative trait data on a sample of individuals can use the POPout software here to perform the POPout test on single or multiple traits and to produce output files that provide the results and figures for illustration.
Download Links
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Overview
- POPout code is available in R and in Python3. Users can use either version.
- For more information on installing dependencies, please refer to Requirements.
- To run POPOut using toy data see our Quick Start Tutorial..
- Following the Quick Start, the full guide provides more information on the theory and the options regarding POPout.
Citation: Our manuscript is currently under review
Please cite our preprint:
Souaiaia, Tade et al. “Striking Departures from Polygenic Architecture in the Tails of Complex Traits.” bioRxiv : the preprint server for biology 2024.11.18.624155. 20 Nov. 2024, doi:10.1101/2024.11.18.624155. Preprint.
To use the family-based STANDout test described in the manuscript please go to: www.sibarc.net.
Contact
For questions about the methodology, this website, or our manuscript please contact Dr Tade Souaiaia or Dr Paul O'Reilly. For source code and coding issues please visit the POPout github page here.